Details for International Conference on the Radiological Protection of Patients Malaga, Spain 26-30 March 2001 Working Material-Contributed Papers Part III.

Autor(es): IAEA

202,p.   

The biodistribution of radiopharmaceuticals may be modified by drug interaction. Unknowledge of such factor can induce a poor misvisualization of the scintigraphy images, leading to the repetition of the examination, increasing the radiation dose for the patient. We are trying to develop a model to evaluate the influence of drugs on the biodistribution of radiopharmaceuticals. Mitomycin-C is a drug that has been used as a component of many chemotherapeutic regimens. We have studied the effect of mitomycin-C on the biodistribution of the pyrophosphate labeled with technetium-99m. These results can be justified by the metabolic process and/or the therapeutical effect of mitomycin-C and this alteration on the biodistribution of the studied radiopharmaceutical was capable to increase the radiation dose in some organs.