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Helen E. Jenkins, M.Sc., R. Bruce Aylward, M.D., Alex Gasasira, M.B., Ch.B., Christl A. Donnelly, Sc.D., Michael Mwanza, B.Comm., Jukka Corander, Ph.D., Sandra Garnier, B.Sc., Claire Chauvin, R.N., M.P.H., Emmanuel Abanida, M.P.H., Muhammad Ali Pate, M.D., Festus Adu, D.V.M., Ph.D., Marycelin Baba, Ph.D. and Nicholas C. Grassly, D.Phil. N Engl J Med 2010; 362:2360-2369 June 24, 2010
Full text, with graphics, is at: http://www.nejm.org/doi/full/10.1056/NEJMoa0910074#articleTop
Background
The largest recorded outbreak of a circulating vaccine-derived poliovirus (cVDPV), detected in Nigeria, provides a unique opportunity to analyze the pathogenicity of the virus, the clinical severity of the disease, and the effectiveness of control measures for cVDPVs as compared with wild-type poliovirus (WPV). |