2004, 412 pp.
ISBN 92 75 11596 6 4
Code: SP 596
Price: US$ 62.00/
US$ 46.00 in Latin America and the Caribbean
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Vaccines: Preventing Disease and Protecting Health is now available in electronic format!

Note: please read a corrigendum for chapter "Oral Vaccines Derived from Transgenic Plants"

In subsequent sections, the authors examine innovative efforts underway to test the efficacy of vaccines against diseases such as meningococcal infection in Africa, Haemophilus influenza type b, varicella, and hepatitis A, and look at efforts to develop a new generation of vaccines against cholera and typhoid, shigella, and Helicobacter pylori. The advances in influenza vaccine development and Hepatitis C are also presented.

The book includes sections on the quest for vaccines against tuberculosis, HIV/AIDS, dengue, malaria, and hookworm. New concepts for vaccine development, adjuvants and delivery systems such as maternal immunization, DNA vaccines, and oral vaccines derived from transgenic plants are also discussed.

Later sections deal with the use of vaccines against potential bioterrorism attacks, with a particular emphasis on smallpox and anthrax. Regulatory and safety issues related to vaccines are also presented from the various perspectives of the public sector, the pharmaceutical industry, and the vaccine consumer.

The final chapter highlights the ongoing challenges of vaccine development, disease prevention, internal and external financing and sustainability of immunization programs, and the impact of health sector reform on these issues.

Dr. Ciro A. de Quadros, the book’s technical editor, also contributed significant chapters to the book. The roster of authors reads like a "Who's Who" in public health and in vaccine development and use. These men and women are the best scientists in their fields. They are breaking new ground in vaccines and immunization programs, bringing the promise of health to the world's populations.

Preface (30.5 KB) Introduction (33.4 KB) Authors and Affiliation (39.5 KB) SETTING THE STAGE Vaccines and the Challenge of Emerging and Re-Emerging Diseases: From HIV/AIDS to Bioterrorism Anthony S. Fauci A Century of Vaccines and Immunization in the Americas (107.8 KB) Ciro A. de Quadros PART I. THE PRESENT Polio: Present Status and Post-Eradication Policies Daniel Tarantola Potential for Circulation of Vaccine-derived Polioviruses Philip Minor Is Global Measles Eradication Feasible? Ciro A. de Quadros New Measles Vaccine Formulations and Delivery Systems and their Potential Contribution to Reducing Measles Mortality Worldwide Maria Teresa Aguado and Ana-Maria Henao-Restrepo The Burden of Congenital Rubella Syndrome Louis Z. Cooper Accelerated Control of Rubella and Prevention of Congenital Rubella Syndrome: Experiences in the Americas Gina Tambini, Carlos Castillo-Solórzano, Mónica Brana, and Ciro A. de Quadros The Challenge of Yellow Fever Thomas P. Monath PART II. THE CUTTING EDGE Haemophilus Influenzae Type B: The Burden in Asia John Clemens and Paul Kilgore Development of a Live Varicella Vaccine: Current Status and Prospects Michiaki Takahashi Hepatitis A Vaccines Stanley M. Lemon Conjugate Meningococcal Vaccines for Africa F. Marc LaForce The Efficacy and Effectiveness of Pneumococcal Conjugate Vaccines Keith P. Klugman PART III. THE FUTURE Rotavirus Vaccines Roger Glass, Umesh Parashar, Joseph Bresee, Jon Gentsch, Reina Turcios, and Baoming Jiang Typhoid Fever and Cholera Vaccines Myron M. Levine Progress in Shigella Vaccine Development Karen L. Kotloff Human Papillomavirus Ian H. Frazer Success in Vaccinating against Helicobacter pylori Steven J. Czinn Hepatitis C Stephen Coates, Qui-Lim Choo, George Kuo, Kevin Crawford, Christine Dong, Mark Wininger, Amy Weiner, Sergio Abrignani, and Michael Houghton Advances in Influenza Vaccine Development John Treanor Vaccine Prospects for Respiratory Syncytial Virus Peter F. Wright PART IV. THE QUEST A New Generation of Tuberculosis Vaccines Michael J. Brennan A New Polio Vaccine? Jeronimo Cello, Nadia De Jesus, Konstantin Chumakov, Jiang Yin, Aniko V. Paul, Matthias Gromeier, and Eckard Wimmer The Quest for a Preventive Vaccine Against HIV/AIDS José Esparza Dengue Vaccines David W. Vaughn Progress Toward a Malaria Vaccine Regina Rabinovich Hookworm in the Americas: Progress in the Development of an Anti-hookworm Vaccine Peter J. Hotez PART V. NEW CONCEPTS FOR VACCINE DEVELOPMENT, ADJUVANTS, AND DELIVERY SYSTEMS Mucosal Vaccines to Induce Cellular Immunity Against HIV and Other Viral Infections Jay A. Berzofsky and Igor M. Belyakov Maternal Immunization W. Paul Glezen DNA Vaccines: A Review Margaret A. Liu Oral Vaccines Derived from Transgenic Plants Charles J. Arntzen, Richard T. Mahoney, Hugh S. Mason, and Dwayne D. Kirk New Adjuvants Nathalie Garçon and Moncef Slauoi The PowderJect Particle-mediated Epidermal Delivery of DNA Vaccines: A New Technology John Beadle VI. VACCINES AND BIOTERRORISM Smallpox Vaccine Donald A. Henderson Anthrax Arthur M. Friedlander Vaccines Against Viral Hemorrhagic Fevers Clarence J. Peters VII. REGULATORY AND SAFETY ISSUES The Public Sector Perspective Manfred Haase The Industry Perspective Luis Barreto The Consumers’ Perspective David Salisbury VIII. VACCINES, PREVENTION, AND PUBLIC HEALTH The Role of Prevention in Health and Public Health: Challenges for the Future Carlyle Guerra de Macedo External Finance of Immunization Programs: Time for a Change in Paradigm? Dean T. Jamison A Vision for the Future Sustainability of National Financing of Immunization Programs Julio Frenk Mora, Roberto Tapia Conyer, and José Ignacio Santos The Role of Multilateral Financing Institutions in Supporting Immunization Programs Alfredo Solari The Potential Impact of Health Reform on Immunization Programs Fernando Muñoz, Oscar Arteaga, Sergio Muñoz, and Mario I. Tarride Perspectives for the Elimination/Eradication of Diseases with Vaccines Walter R. Dowdle EPILOGUE: CONFERENCE ON VACCINES, PREVENTION, AND PUBLIC HEALTH: A VISION FOR THE FUTURE Welcoming Remarks George A.O. Alleyne Summation Donald A. Henderson Meeting Agenda List of Participants